Version 5.4
Mus musculus Protein: Entpd7
Summary
InnateDB Protein IDBP-168284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Entpd7
Protein Name ectonucleoside triphosphate diphosphohydrolase 7
Synonyms 1810012B13Rik; 1810020C02Rik; 2810003F23Rik; LALP1; Lysal2;
Species Mus musculus
Ensembl Protein ENSMUSP00000079864
InnateDB Gene IDBG-168282 (Entpd7)
Protein Structure
UniProt Annotation
Function Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes to intracellular vesicular compartments. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in brain, kidney, liver and testis. Weakly expressed in lung, thymus and heart. {ECO:0000269PubMed:11278936}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0009191 ribonucleoside diphosphate catabolic process
GO:0009203 ribonucleoside triphosphate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:2135885
InterPro IPR000407 Nucleoside phosphatase GDA1/CD39
PFAM PF01150
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TCT4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 93685
UniGene Mm.296789
RefSeq NP_444333
MGI ID
MGI Symbol Entpd7
OMIM
CCDS CCDS29835
HPRD
IMGT
EMBL AF288221 AK147401 AK166220 AK170546 AK220284 BC137709 BC137717
GenPept AAG01009 AAI37710 AAI37718 BAD90209 BAE27889 BAE38638 BAE41871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca