InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bik

Summary

InnateDB Protein

IDBP-168306.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bik

Protein Name

BCL2-interacting killer

Synonyms

Biklk; Blk; Nbk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016902

InnateDB Gene

IDBG-168304 (Bik)

Protein Structure

UniProt Annotation

Function

Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity. {ECO:0000269PubMed:9525867}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000269PubMed:9525867}; Single-pass membrane protein {ECO:0000269PubMed:9525867}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis, kidney, liver, lung and heart. {ECO:0000269PubMed:9525867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0051400	BH domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0008637	apoptotic mitochondrial changes
GO:0032464	positive regulation of protein homooligomerization
GO:0090200	positive regulation of release of cytochrome c from mitochondria