Version 5.4
Mus musculus Protein: Tmem38a
Summary
InnateDB Protein IDBP-168345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem38a
Protein Name transmembrane protein 38A
Synonyms 1110001E17Rik; AI413399; mg33a; TRIC-A;
Species Mus musculus
Ensembl Protein ENSMUSP00000034244
InnateDB Gene IDBG-168343 (Tmem38a)
Protein Structure
UniProt Annotation
Function Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000269PubMed:17611541}.
Subcellular Localization Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney. {ECO:0000269PubMed:17611541}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0015672 monovalent inorganic cation transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1921416
InterPro IPR007866 TRIC channel
PFAM PF05197
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TMP8
PhosphoSite PhosphoSite-Q3TMP8
TrEMBL
UniProt Splice Variant
Entrez Gene 74166
UniGene
RefSeq NP_653117
MGI ID
MGI Symbol Tmem38a
OMIM
CCDS CCDS22417
HPRD
IMGT
EMBL AB261158 AK157969 AK165818 BC014728 BC024788 EF988666
GenPept AAH14728 AAH24788 ABS17665 BAE34290 BAE38393 BAF62541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca