Version 5.4
Mus musculus Protein: Sprr2a3
Summary
InnateDB Protein IDBP-168380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sprr2a3
Protein Name small proline-rich protein 2A3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000088387
InnateDB Gene IDBG-168378 (Sprr2a3)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008544 epidermis development
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3845028
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQK8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 20755
UniGene Mm.359329
RefSeq
MGI ID
MGI Symbol Sprr2a3
OMIM
CCDS
HPRD
IMGT
EMBL AJ005559 AK003391 AK007633 AK007928 AK008631 AK008887 AK009238 AK009790 AK147183 AK168529 AY158986 BC010818 BC099393 CH466656
GenPept AAH10818 AAH99393 AAN86823 BAB22758 BAB25150 BAB25355 BAB25793 BAB25953 BAB26159 BAB26506 BAE27745 BAE40407 CAA06588 EDL00710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca