InnateDB Protein
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IDBP-168398.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kctd8
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Protein Name
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potassium channel tetramerisation domain containing 8
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000084484
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InnateDB Gene
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IDBG-168394 (Kctd8)
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Protein Structure
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Function |
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. {ECO:0000269PubMed:20400944}.
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Subcellular Localization |
Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0051260
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protein homooligomerization
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Cellular Component |
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PDB ID |
MGI:2443804
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InterPro |
IPR000210
BTB/POZ-like
IPR003131
Potassium channel tetramerisation-type BTB domain
IPR011333
BTB/POZ fold
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PFAM |
PF02214
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PRINTS |
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PIRSF |
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SMART |
SM00225
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TIGRFAMs |
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Modification |
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SwissProt |
Q50H33
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PhosphoSite |
PhosphoSite-Q50H33
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
243043
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UniGene |
Mm.407725
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RefSeq |
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MGI ID |
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MGI Symbol |
Kctd8
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK039167
AK042569
AK043351
AK045439
AK082563
AY615967
BC116940
BC116942
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GenPept |
AAI16941
AAI16943
AAU25822
BAC30262
BAC31296
BAC31527
BAC32368
BAC38532
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