Version 5.4
Mus musculus Protein: Sprr2d
Summary
InnateDB Protein IDBP-168445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sprr2d
Protein Name small proline-rich protein 2D
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039821
InnateDB Gene IDBG-168443 (Sprr2d)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in uterus. {ECO:0000269PubMed:15232223}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008544 epidermis development
GO:0008585 female gonad development
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
GO:0032355 response to estradiol
Cellular Component
GO:0001533 cornified envelope
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1330347
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70555
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 20758
UniGene Mm.87820
RefSeq NP_035600
MGI ID
MGI Symbol Sprr2d
OMIM
CCDS CCDS38510
HPRD
IMGT
EMBL AJ005562 AK008778 AY158988
GenPept AAN86825 BAC25232 CAA06591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca