Version 5.4
Mus musculus Protein: Sin3b
Summary
InnateDB Protein IDBP-168507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sin3b
Protein Name transcriptional regulator, SIN3B (yeast)
Synonyms 2810430C10Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000004494
InnateDB Gene IDBG-168505 (Sin3b)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. {ECO:0000269PubMed:10620510, ECO:0000269PubMed:7889570}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00810, ECO:0000269PubMed:20170641, ECO:0000269PubMed:7889570}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007519 skeletal muscle tissue development
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048738 cardiac muscle tissue development
Cellular Component
GO:0000805 X chromosome
GO:0000806 Y chromosome
GO:0001741 XY body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030849 autosome
Protein Structure and Domains
PDB ID MGI:107158
InterPro IPR003822 Paired amphipathic helix
IPR013194 Histone deacetylase interacting
PFAM PF02671
PF08295
PRINTS
PIRSF
SMART SM00761
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62141
PhosphoSite PhosphoSite-Q62141
TrEMBL
UniProt Splice Variant
Entrez Gene 20467
UniGene Mm.487812
RefSeq NP_033214
MGI ID 2F05
MGI Symbol Sin3b
OMIM
CCDS CCDS52599
HPRD
IMGT
EMBL AF038848 AK173005 BC020049 BC021160 L38622
GenPept AAA69774 AAC04821 AAH20049 AAH21160 BAD32283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca