InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Orc4

Summary

InnateDB Protein

IDBP-168510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Orc4

Protein Name

origin recognition complex, subunit 4

Synonyms

mMmORC4; Orc4l; Orc4P;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028098

InnateDB Gene

IDBG-168508 (Orc4)

Protein Structure

UniProt Annotation

Function

Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006810	transport

Cellular Component

GO:0000808	origin recognition complex
GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex

Protein Structure and Domains

PDB ID

MGI:1347043

InterPro

IPR001482 Type II secretion system protein E
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR011579 ATPase domain, prokaryote
IPR016527 Origin recognition complex, subunit 4
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00437
PF00004
PF07724
PF13304
PF01637

PRINTS

PIRSF

PIRSF007858

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt