InnateDB Protein
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IDBP-168557.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Maml1
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Protein Name
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mastermind like 1 (Drosophila)
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Synonyms
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AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059210
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InnateDB Gene
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IDBG-168553 (Maml1)
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Protein Structure
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Function |
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269PubMed:15019995, ECO:0000269PubMed:15187027}.
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Subcellular Localization |
Nucleus speckle {ECO:0000269PubMed:15019995}. Note=Nuclear, in a punctate manner.
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Disease Associations |
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Tissue Specificity |
At E9.5, strongly expressed in the telencephalon, first branchial arch, forelimb buds and somites. By E10.5, continuously expressed in brain and spinal cord. Also expressed in first and second branchial arches and limb buds. By E11.5, expression in CNS is weak but increases in mesodermal tissues. At E14.5, detected in epithelial cells in trachea, esophagus and proximal and distal tubules of the developing lungs. {ECO:0000269PubMed:15019995}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1890504
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InterPro |
IPR019082
Neurogenic mastermind-like, N-terminal
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PFAM |
PF09596
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6T264
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PhosphoSite |
PhosphoSite-Q6T264
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
103806
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UniGene |
Mm.51116
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RefSeq |
NP_780543
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MGI ID |
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MGI Symbol |
Maml1
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OMIM |
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CCDS |
CCDS24632
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HPRD |
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IMGT |
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EMBL |
AK086146
AK129088
AL646002
AY442299
BC024668
BC058658
BC094599
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GenPept |
AAH24668
AAH58658
AAH94599
AAS07633
BAC39618
BAC97898
CAI24683
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