Version 5.4
Mus musculus Protein: Prkag3
Summary
InnateDB Protein IDBP-168635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkag3
Protein Name protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000080342
InnateDB Gene IDBG-168633 (Prkag3)
Protein Structure
UniProt Annotation
Function AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0019901 protein kinase binding
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0005978 glycogen biosynthetic process
GO:0006633 fatty acid biosynthetic process
GO:0015758 glucose transport
Cellular Component
GO:0005829 cytosol
GO:0031588 AMP-activated protein kinase complex
Protein Structure and Domains
PDB ID MGI:1891343
InterPro IPR000644 CBS domain
PFAM PF00571
PRINTS
PIRSF
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGM7
PhosphoSite PhosphoSite-Q8BGM7
TrEMBL
UniProt Splice Variant
Entrez Gene 241113
UniGene Mm.166501
RefSeq
MGI ID
MGI Symbol Prkag3
OMIM
CCDS CCDS15055
HPRD
IMGT
EMBL AF525500 AF525501 AK036585 AY263402 BC116749 BC116777
GenPept AAI16750 AAI16778 AAN47137 AAN47138 AAP22981 BAC29492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca