Version 5.4
Mus musculus Protein: AI428936
Summary
InnateDB Protein IDBP-168643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AI428936
Protein Name expressed sequence AI428936
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000055874
InnateDB Gene IDBG-168641 (AI428936)
Protein Structure
UniProt Annotation
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. {ECO:0000250, ECO:0000269PubMed:19164528}.
Subcellular Localization Nucleus outer membrane {ECO:0000269PubMed:19164528, ECO:0000269PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269PubMed:19164528, ECO:0000269PubMed:23348741}. Note=Localization at the nucleus outer membrane location requires the presence of SUN1.
Disease Associations
Tissue Specificity Expressed in secretory epithelial cells, such as those found in exocrine pancreas, bulbourethral gland, mammary gland and salivary gland (at protein level). Also expressed in the cochlea, where it is restricted primarily to the 3 rows of outer hair cells and 1 row of inner hair cells (at protein level). Not detected in other cells of the cochlea, including Deiter's cells and pillar cells, nor in liver and kidney (at protein level). {ECO:0000269PubMed:19164528, ECO:0000269PubMed:23348741}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0045198 establishment of epithelial cell apical/basal polarity
Cellular Component
GO:0016021 integral component of membrane
GO:0031309 integral to nuclear outer membrane
Protein Structure and Domains
PDB ID MGI:2141950
InterPro IPR012315 KASH domain
PFAM PF10541
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CII8
PhosphoSite PhosphoSite-Q8CII8
TrEMBL
UniProt Splice Variant
Entrez Gene 233066
UniGene Mm.421492
RefSeq NP_705805
MGI ID
MGI Symbol Syne4
OMIM
CCDS CCDS21086
HPRD
IMGT
EMBL BC004761 BC023803 BC056649
GenPept AAH04761 AAH23803 AAH56649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca