Version 5.4
Mus musculus Protein: Sprr1a
Summary
InnateDB Protein IDBP-168667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sprr1a
Protein Name small proline-rich protein 1A
Synonyms AI528815; mSPRR1A; SPR1a;
Species Mus musculus
Ensembl Protein ENSMUSP00000053751
InnateDB Gene IDBG-168665 (Sprr1a)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus. {ECO:0000269PubMed:8601731}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0018149 peptide cross-linking
GO:0031424 keratinization
Cellular Component
GO:0005737 cytoplasm
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID MGI:106660
InterPro IPR003302 Cornifin (SPRR1)
PFAM PF02389
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62266
PhosphoSite PhosphoSite-Q62266
TrEMBL
UniProt Splice Variant
Entrez Gene 20753
UniGene
RefSeq NP_033290
MGI ID
MGI Symbol Sprr1a
OMIM
CCDS CCDS17559
HPRD
IMGT
EMBL AF057156 AK144782 BC027534 CH466656 X91824
GenPept AAD10126 AAH27534 BAE26064 CAA62933 EDL00695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca