InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrfn3

Summary

InnateDB Protein

IDBP-168718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrfn3

Protein Name

leucine rich repeat and fibronectin type III domain containing 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037616

InnateDB Gene

IDBG-168716 (Lrfn3)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. {ECO:0000269PubMed:18227064, ECO:0000269PubMed:18585462}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16828986}; Single-pass type I membrane protein {ECO:0000269PubMed:16828986}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, testis, stomach, small intestine and kidney. Residually expressed in heart, lung, liver, skeletal muscle and uterus. In the brain, weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. {ECO:0000269PubMed:16828986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2442512

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM