InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fev

Summary

InnateDB Protein

IDBP-168816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fev

Protein Name

FEV (ETS oncogene family)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070878

InnateDB Gene

IDBG-168814 (Fev)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269PubMed:12546819, ECO:0000269PubMed:14602809, ECO:0000269PubMed:17656160}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:11875656}.

Disease Associations

Tissue Specificity

Expressed in central serotonergic neurons. {ECO:0000269PubMed:11875656}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0042551	neuron maturation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048665	neuron fate specification