InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HRAS

Summary

InnateDB Protein

IDBP-16882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRAS

Protein Name

v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Synonyms

C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; p21ras; RASH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000309845

InnateDB Gene

IDBG-16878 (HRAS)

Protein Structure

UniProt Annotation

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. {ECO:0000269PubMed:12740440, ECO:0000269PubMed:14500341, ECO:0000269PubMed:9020151}.

Subcellular Localization

Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GNB2L1 to the perinuclear region.

Disease Associations

Faciocutaneoskeletal syndrome (FCSS) [MIM:218040]: A rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. {ECO:0000269PubMed:16170316, ECO:0000269PubMed:16329078, ECO:0000269PubMed:16443854, ECO:0000269PubMed:17054105, ECO:0000269PubMed:18039947, ECO:0000269PubMed:18247425, ECO:0000269PubMed:19995790}. Note=The disease is caused by mutations affecting the gene represented in this entry.Congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040]: Variant of Costello syndrome. {ECO:0000269PubMed:17412879}. Note=The disease is caused by mutations affecting the gene represented in this entry.Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. {ECO:0000269PubMed:12727991}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Mutations which change positions 12, 13 or 61 activate the potential of HRAS to transform cultured cells and are implicated in a variety of human tumors.Bladder cancer (BLC) [MIM:109800]: A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas that begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Defects in HRAS are the cause of oral squamous cell carcinoma (OSCC).Schimmelpenning-Feuerstein-Mims syndrome (SFM) [MIM:163200]: A disease characterized by sebaceous nevi, often on the face, associated with variable ipsilateral abnormalities of the central nervous system, ocular anomalies, and skeletal defects. Many oral manifestations have been reported, not only including hypoplastic and malformed teeth, and mucosal papillomatosis, but also ankyloglossia, hemihyperplastic tongue, intraoral nevus, giant cell granuloma, ameloblastoma, bone cysts, follicular cysts, oligodontia, and odontodysplasia. Sebaceous nevi follow the lines of Blaschko and these can continue as linear intraoral lesions, as in mucosal papillomatosis. {ECO:0000269PubMed:22683711}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:14500341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 132 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	132 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0006184	GTP catabolic process
GO:0006935	chemotaxis
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0010629	negative regulation of gene expression
GO:0015031	protein transport
GO:0015684	ferrous iron transport
GO:0030335	positive regulation of cell migration
GO:0032855	positive regulation of Rac GTPase activity
GO:0034259	negative regulation of Rho GTPase activity
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050900	leukocyte migration
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090303	positive regulation of wound healing
GO:0090398	cellular senescence
GO:1900029	positive regulation of ruffle assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000630	positive regulation of miRNA metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF02421
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt