Version 5.4
Mus musculus Protein: Tcl1
Summary
InnateDB Protein IDBP-169128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcl1
Protein Name T-cell lymphoma breakpoint 1
Synonyms Tcl1a;
Species Mus musculus
Ensembl Protein ENSMUSP00000036066
InnateDB Gene IDBG-169124 (Tcl1)
Protein Structure
UniProt Annotation
Function Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10716693}. Nucleus {ECO:0000269PubMed:10716693}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Microsomal fraction. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0019827 stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005938 cell cortex
GO:0045120 pronucleus
Protein Structure and Domains
PDB ID MGI:1097166
InterPro IPR004832 TCL1/MTCP1
PFAM PF01840
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56280
PhosphoSite PhosphoSite-P56280
TrEMBL
UniProt Splice Variant
Entrez Gene 21432
UniGene Mm.18154
RefSeq NP_033363
MGI ID 1JNP
MGI Symbol Tcl1
OMIM
CCDS CCDS36549
HPRD
IMGT
EMBL AF031956 BC052336 Y15376
GenPept AAB87461 AAH52336 CAA75599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca