InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chuk

Summary

InnateDB Protein

IDBP-169134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chuk

Protein Name

conserved helix-loop-helix ubiquitous kinase

Synonyms

AI256658; Chuk1; Fbx24; Fbxo24; IKBKA; IKK1; Ikka; NFKBIKA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026217

InnateDB Gene

IDBG-169132 (Chuk)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	159 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding

Biological Process

GO:0001101	response to acid
GO:0002011	morphogenesis of an epithelial sheet
GO:0003009	skeletal muscle contraction
GO:0006468	protein phosphorylation
GO:0007252	I-kappaB phosphorylation
GO:0007266	Rho protein signal transduction
GO:0007595	lactation
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0023014	signal transduction by phosphorylation
GO:0030316	osteoclast differentiation
GO:0032496	response to lipopolysaccharide
GO:0033194	response to hydroperoxide
GO:0033598	mammary gland epithelial cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200	response to amino acid
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051146	striated muscle cell differentiation
GO:0060749	mammary gland alveolus development
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008385	IkappaB kinase complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:99484

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022007 I-kappa-kinase-beta NEMO binding domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF12179

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt