InnateDB Protein
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IDBP-169246.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Oma1
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Protein Name
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OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
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Synonyms
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2010001O09Rik; MPRP-1; ZMPOMA1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045269
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InnateDB Gene
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IDBG-169244 (Oma1)
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Protein Structure
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Function |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000269PubMed:20038678, ECO:0000269PubMed:22433842}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000305PubMed:20038678}; Multi-pass membrane protein {ECO:0000305PubMed:20038678}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914263
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InterPro |
IPR001915
Peptidase M48
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PFAM |
PF01435
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8H7
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PhosphoSite |
PhosphoSite-Q9D8H7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67013
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UniGene |
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RefSeq |
NP_080185
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MGI ID |
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MGI Symbol |
Oma1
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OMIM |
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CCDS |
CCDS18412
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HPRD |
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IMGT |
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EMBL |
AK008020
AK076209
AK136208
AL772338
BC016238
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GenPept |
AAH16238
BAB25414
BAC36255
BAE22875
CAM25530
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