Version 5.4
Mus musculus Protein: Iqsec1
Summary
InnateDB Protein IDBP-169374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iqsec1
Protein Name IQ motif and Sec7 domain 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000098712
InnateDB Gene IDBG-169366 (Iqsec1)
Protein Structure
UniProt Annotation
Function In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1196356
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000904 Sec7 domain
PFAM PF00612
PF01369
PRINTS
PIRSF
SMART SM00015
SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R0S2
PhosphoSite PhosphoSite-Q8R0S2
TrEMBL
UniProt Splice Variant
Entrez Gene 232227
UniGene Mm.196943
RefSeq NP_001127855
MGI ID
MGI Symbol Iqsec1
OMIM
CCDS CCDS51850
HPRD
IMGT
EMBL AC121954 AK157963 AK220355 BC026481
GenPept AAH26481 BAD90418 BAE34286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca