InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prop1

Summary

InnateDB Protein

IDBP-169410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prop1

Protein Name

paired like homeodomain factor 1

Synonyms

df; Prop-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057231

InnateDB Gene

IDBG-169408 (Prop1)

Protein Structure

UniProt Annotation

Function

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0006355	regulation of transcription, DNA-templated
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0016477	cell migration
GO:0021979	hypothalamus cell differentiation
GO:0021984	adenohypophysis development
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048732	gland development
GO:0048850	hypophysis morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060126	somatotropin secreting cell differentiation