InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bloc1s2a

Summary

InnateDB Protein

IDBP-169428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bloc1s2a

Protein Name

biogenesis of lysosome-related organelles complex-1, subunit 2

Synonyms

2410089B13Rik; Bloc1s2a; BLOS2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078042

InnateDB Gene

IDBG-169426 (Bloc1s2a)

Protein Structure

UniProt Annotation

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation. {ECO:0000269PubMed:16760431, ECO:0000269PubMed:19546860, ECO:0000269PubMed:21998198}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to the centrosomes in a microtubule- dependent manner. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0008089	anterograde axon cargo transport
GO:0008284	positive regulation of cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0031175	neuron projection development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048490	anterograde synaptic vesicle transport
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0031083	BLOC-1 complex
GO:0055037	recycling endosome