InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp14

Summary

InnateDB Protein

IDBP-169487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp14

Protein Name

caspase 14

Synonyms

MICE; mini-ICE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005488

InnateDB Gene

IDBG-169485 (Casp14)

Protein Structure

UniProt Annotation

Function

Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. {ECO:0000269PubMed:11175259, ECO:0000269PubMed:17515931}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11175259}. Nucleus {ECO:0000269PubMed:11175259}.

Disease Associations

Tissue Specificity

Embryo, adult liver and less in adult brain and kidney. Expressed in differentiating keratinocytes of embryonic skin (at protein level). Expressed in keratinocytes of adult skin suprabasal layers (at protein level). {ECO:0000269PubMed:10203698, ECO:0000269PubMed:11175259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030154	cell differentiation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045095	keratin filament
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1335092

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt