InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc1a6

Summary

InnateDB Protein

IDBP-169556.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc1a6

Protein Name

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Synonyms

EAAT4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005490

InnateDB Gene

IDBG-169554 (Slc1a6)

Protein Structure

UniProt Annotation

Function

Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006835	dicarboxylic acid transport
GO:0015813	L-glutamate transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1096331

InterPro

IPR001991 Sodium:dicarboxylate symporter

PFAM

PF00375

PRINTS

PR00173

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35544

PhosphoSite

PhosphoSite-O35544

TrEMBL

B2RQX4

UniProt Splice Variant

Entrez Gene

20513

UniGene

Mm.6257

RefSeq

NP_033226

MGI ID

MGI Symbol

Slc1a6

OMIM

CCDS

CCDS23970

HPRD

IMGT

EMBL

BC138120 BC138140 CH466553 D83262

GenPept

AAI38121 AAI38141 BAA23640 EDL31716