InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C8b

Summary

InnateDB Protein

IDBP-169583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C8b

Protein Name

complement component 8, beta polypeptide

Synonyms

4930439B20Rik; AI595927;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031663

InnateDB Gene

IDBG-169581 (C8b)

Protein Structure

UniProt Annotation

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:88236

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001862 Membrane attack complex component/perforin/complement C9
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR020864 Membrane attack complex component/perforin (MACPF) domain

PFAM

PF00090
PF00057
PF01823

PRINTS

PR00764
PR00261

PIRSF

SMART

SM00209
SM00192
SM00457

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt