InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcb6

Summary

InnateDB Protein

IDBP-169782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb6

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 6

Synonyms

1200005B17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027396

InnateDB Gene

IDBG-169780 (Abcb6)

Protein Structure

UniProt Annotation

Function

Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. {ECO:0000269PubMed:17006453}.

Subcellular Localization

Cell membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endosome {ECO:0000269PubMed:17006453, ECO:0000269PubMed:23519333}. Note=localized to the endosome-like compartement and dendrite tips.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0015439	heme-transporting ATPase activity
GO:0015562	efflux transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0020037	heme binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006810	transport
GO:0007420	brain development
GO:0015886	heme transport
GO:0043588	skin development
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1921354

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DC29