InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mina

Summary

InnateDB Protein

IDBP-169836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mina

Protein Name

myc induced nuclear antigen

Synonyms

1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023407

InnateDB Gene

IDBG-169834 (Mina)

Protein Structure

UniProt Annotation

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000250, ECO:0000269PubMed:16533354}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16533354}. Nucleus, nucleolus {ECO:0000269PubMed:16533354}.

Disease Associations

Tissue Specificity

Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level). {ECO:0000269PubMed:16533354}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0042127	regulation of cell proliferation
GO:0042254	ribosome biogenesis
GO:0055114	oxidation-reduction process