InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scd1

Summary

InnateDB Protein

IDBP-169842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scd1

Protein Name

stearoyl-Coenzyme A desaturase 1

Synonyms

AA589638; ab; AI265570; Scd; Scd-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036936

InnateDB Gene

IDBG-169840 (Scd1)

Protein Structure

UniProt Annotation

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16275639}; Multi-pass membrane protein {ECO:0000269PubMed:16275639}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004768	stearoyl-CoA 9-desaturase activity
GO:0005506	iron ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0008610	lipid biosynthetic process
GO:0010873	positive regulation of cholesterol esterification
GO:0034435	cholesterol esterification
GO:0044130	negative regulation of growth of symbiont in host
GO:0050830	defense response to Gram-positive bacterium
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0055114	oxidation-reduction process