Version 5.4
Mus musculus Protein: Them4
Summary
InnateDB Protein IDBP-169847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Them4
Protein Name thioesterase superfamily member 4
Synonyms 2700077M13Rik; 4921507I02Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000062841
InnateDB Gene IDBG-169843 (Them4)
Protein Structure
UniProt Annotation
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016290 palmitoyl-CoA hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0016032 viral process
GO:0043491 protein kinase B signaling
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0032587 ruffle membrane
Protein Structure and Domains
PDB ID MGI:1923028
InterPro IPR006683 Thioesterase superfamily
IPR029069 HotDog domain
PFAM PF03061
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UUI3
PhosphoSite PhosphoSite-Q3UUI3
TrEMBL
UniProt Splice Variant
Entrez Gene 75778
UniGene Mm.45092
RefSeq NP_083707
MGI ID
MGI Symbol Them4
OMIM
CCDS CCDS38533
HPRD
IMGT
EMBL AK014834 AK038420 AK138397 BC022612 BC134396
GenPept AAH22612 AAI34397 BAB29572 BAC29995 BAE23642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca