InnateDB Protein
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IDBP-16990.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC51B
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Protein Name
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Organic solute transporter subunit beta
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000335292
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InnateDB Gene
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IDBG-16988 (SLC51B)
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Protein Structure
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Function |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. {ECO:0000269PubMed:16317684}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}; Single-pass membrane protein {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
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Disease Associations |
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Tissue Specificity |
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269PubMed:12719432, ECO:0000269PubMed:16317684}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0006810
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transport
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GO:0015721
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bile acid and bile salt transport
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GO:0031647
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regulation of protein stability
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GO:0060050
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positive regulation of protein glycosylation
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GO:0070863
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positive regulation of protein exit from endoplasmic reticulum
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GO:0090314
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positive regulation of protein targeting to membrane
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86UW2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
123264
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UniGene |
Hs.534533
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RefSeq |
NP_849190
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HUGO |
HGNC:29956
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OMIM |
612085
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CCDS |
CCDS10199
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HPRD |
17811
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IMGT |
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EMBL |
AY194242
BC103842
BC103843
BC103844
CH471082
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GenPept |
AAI03843
AAI03844
AAI03845
AAP23992
EAW77708
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