Version 5.4
Homo sapiens Protein: NCLN
Summary
InnateDB Protein IDBP-16996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCLN
Protein Name nicalin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000246117
InnateDB Gene IDBG-16994 (NCLN)
Protein Structure
UniProt Annotation
Function May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15257293, ECO:0000269PubMed:20538592}; Single-pass membrane protein {ECO:0000269PubMed:15257293, ECO:0000269PubMed:20538592}.
Disease Associations
Tissue Specificity Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269PubMed:15257293}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009966 regulation of signal transduction
GO:0016485 protein processing
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007484 Peptidase M28
IPR008710 Nicastrin
IPR016574 Nicalin
PFAM PF04389
PF05450
PRINTS
PIRSF PIRSF011018
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969V3
PhosphoSite PhosphoSite-Q969V3
TrEMBL K7EMW4
UniProt Splice Variant
Entrez Gene 56926
UniGene Hs.733745
RefSeq NP_064555
HUGO HGNC:26923
OMIM 609156
CCDS CCDS32869
HPRD 07126
IMGT
EMBL AC005331 AC011547 AK172848 AK314044 AL136567 AL365369 BC003076 BC007275 BC008920 BC010064 BC013283 BC019091 BC025926 CH471139 CR533566
GenPept AAC27667 AAH03076 AAH07275 AAH08920 AAH10064 AAH13283 AAH19091 AAH25926 BAD18812 BAG36753 CAB66502 CAB96945 CAG38597 EAW69330 EAW69333 EAW69335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca