Version 5.4
Mus musculus Protein: Rorc
Summary
InnateDB Protein IDBP-169974.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Rorc
Protein Name RAR-related orphan receptor gamma
Synonyms Nr1f3; RORgamma; Thor; TOR;
Species Mus musculus
Ensembl Protein ENSMUSP00000096476
InnateDB Gene IDBG-169968 (Rorc)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 5 [view]
Protein-DNA 22 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0033077 T cell differentiation in thymus
GO:0043401 steroid hormone mediated signaling pathway
GO:0045586 regulation of gamma-delta T cell differentiation
GO:0046632 alpha-beta T cell differentiation
GO:0048535 lymph node development
GO:0048537 mucosal-associated lymphoid tissue development
GO:0072539 T-helper 17 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:104856
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
IPR003079 Nuclear receptor ROR
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00105
PRINTS PR00047
PR01293
PIRSF
SMART SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q8I1
UniProt Splice Variant
Entrez Gene 19885
UniGene Mm.4372
RefSeq
MGI ID
MGI Symbol Rorc
OMIM
CCDS
HPRD
IMGT
EMBL AC164562
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca