Version 5.4
Mus musculus Protein: Ppap2c
Summary
InnateDB Protein IDBP-169989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppap2c
Protein Name phosphatidic acid phosphatase type 2C
Synonyms Lpp2;
Species Mus musculus
Ensembl Protein ENSMUSP00000069670
InnateDB Gene IDBG-169987 (Ppap2c)
Protein Structure
UniProt Annotation
Function Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P) (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at high levels in lung, liver and kidney; at low levels in heart and brain, and was not detected in skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1354945
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAX2
PhosphoSite PhosphoSite-Q9DAX2
TrEMBL G3XA61
UniProt Splice Variant
Entrez Gene 50784
UniGene Mm.28873
RefSeq NP_056632
MGI ID
MGI Symbol Ppap2c
OMIM
CCDS CCDS35966
HPRD
IMGT
EMBL AC100708 AF123611 AK005452 AK049581 BC010332 CH466553
GenPept AAD24061 AAH10332 BAB24045 BAC33824 EDL31694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca