InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbln2

Summary

InnateDB Protein

IDBP-170005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbln2

Protein Name

fibulin 2

Synonyms

5730577E14Rik; FIBL-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048334

InnateDB Gene

IDBG-170003 (Fbln2)

Protein Structure

UniProt Annotation

Function

Its binding to fibronectin and some other ligands is calcium dependent.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Component of both basement membranes and other connective tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0010811

positive regulation of cell-substrate adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95488

InterPro

IPR000020 Anaphylatoxin/fibulin
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR018081 Anaphylatoxin, complement system

PFAM

PF01821
PF00008
PF07645

PRINTS

PIRSF

SMART

SM00104
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P37889