Version 5.4
Mus musculus Protein: Theg
Summary
InnateDB Protein IDBP-170147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Theg
Protein Name testicular haploid expressed gene
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000076647
InnateDB Gene IDBG-170145 (Theg)
Protein Structure
UniProt Annotation
Function May be involved (but not essential) in spermatogenesis. {ECO:0000269PubMed:12748127}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11173852, ECO:0000269PubMed:12748127}. Note=Localized predominantly in the nucleus of haploid round spermatid.
Disease Associations
Tissue Specificity Testis specific (at protein level). Specifically expressed in spermatids; Sertoli cells maintain the level of expression in spermatids. If isolated spermatids are cultivated for 16 hours alone, the expression of THEG is down- regulated. May require signals from Sertoli cells to initiate changes in its gene expression through spermatogenesis. {ECO:0000269PubMed:10330110, ECO:0000269PubMed:10747865, ECO:0000269PubMed:11173852, ECO:0000269PubMed:12748127}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1338756
InterPro IPR006623 Testicular haploid expressed repeat
PFAM PF14912
PRINTS
PIRSF
SMART SM00705
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMB1
PhosphoSite PhosphoSite-Q9JMB1
TrEMBL
UniProt Splice Variant
Entrez Gene 21830
UniGene Mm.89197
RefSeq NP_954696
MGI ID
MGI Symbol Theg
OMIM
CCDS CCDS23978
HPRD
IMGT
EMBL AB033128 AJ011834 BC061243
GenPept AAH61243 BAA93717 CAB57454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca