InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl11b

Summary

InnateDB Protein

IDBP-170177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl11b

Protein Name

B-cell leukemia/lymphoma 11B

Synonyms

9130430L19Rik; AI604821; B630002E05Rik; BCL-11B; Ctip2; Rit1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068258

InnateDB Gene

IDBG-170175 (Bcl11b)

Protein Structure

UniProt Annotation

Function

Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. {ECO:0000269PubMed:12717433}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	3 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0003334	keratinocyte development
GO:0003382	epithelial cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007409	axonogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0019216	regulation of lipid metabolic process
GO:0021773	striatal medium spiny neuron differentiation
GO:0021953	central nervous system neuron differentiation
GO:0031077	post-embryonic camera-type eye development
GO:0033077	T cell differentiation in thymus
GO:0033153	T cell receptor V(D)J recombination
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043066	negative regulation of apoptotic process
GO:0043368	positive T cell selection
GO:0043588	skin development
GO:0045087	innate immune response (InnateDB)
GO:0045664	regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046632	alpha-beta T cell differentiation
GO:0048538	thymus development
GO:0071678	olfactory bulb axon guidance