Version 5.4
Mus musculus Protein: Rpp25
Summary
InnateDB Protein IDBP-170196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rpp25
Protein Name ribonuclease P 25 subunit (human)
Synonyms AI851155;
Species Mus musculus
Ensembl Protein ENSMUSP00000079358
InnateDB Gene IDBG-170194 (Rpp25)
Protein Structure
UniProt Annotation
Function Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008033 tRNA processing
GO:0008150 biological_process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005813 centrosome
Protein Structure and Domains
PDB ID MGI:2143151
InterPro IPR002775 DNA/RNA-binding protein Alba-like
PFAM PF01918
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WE3
PhosphoSite PhosphoSite-Q91WE3
TrEMBL
UniProt Splice Variant
Entrez Gene 102614
UniGene Mm.274421
RefSeq NP_598743
MGI ID
MGI Symbol Rpp25
OMIM
CCDS CCDS23222
HPRD
IMGT
EMBL AK082822 BC016085 BC083064
GenPept AAH16085 AAH83064 BAC38636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca