Version 5.4
Homo sapiens Protein: CELF5
Summary
InnateDB Protein IDBP-17031.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELF5
Protein Name CUGBP, Elav-like family member 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292672
InnateDB Gene IDBG-17029 (CELF5)
Protein Structure
UniProt Annotation
Function RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269PubMed:11158314}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain. {ECO:0000269PubMed:11158314}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6W0
PhosphoSite PhosphoSite-Q8N6W0
TrEMBL
UniProt Splice Variant
Entrez Gene 60680
UniGene Hs.655747
RefSeq NP_068757
HUGO HGNC:14058
OMIM 612680
CCDS CCDS12106
HPRD 12535
IMGT
EMBL AB209067 AC005331 AC006505 AC010649 AC123911 AF248649 AF329266 BC028101 CH471139
GenPept AAC27666 AAF86231 AAH28101 AAK07476 BAD92304 EAW69327 EAW69328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca