InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk16

Summary

InnateDB Protein

IDBP-170339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk16

Protein Name

serine/threonine kinase 16

Synonyms

EDPK; Krct; MPSK; PKL12; TSF-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027401

InnateDB Gene

IDBG-170337 (Stk16)

Protein Structure

UniProt Annotation

Function

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000250, ECO:0000269PubMed:9878782}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:9712705}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles.

Disease Associations

Tissue Specificity

Ubiquitously expressed at low levels. Relatively higher levels in testis, kidney and liver. {ECO:0000269PubMed:9712705, ECO:0000269PubMed:9878782}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005798	Golgi-associated vesicle
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1313271

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt