InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Celf3

Summary

InnateDB Protein

IDBP-170386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celf3

Protein Name

CUGBP, Elav-like family member 3

Synonyms

4930415M08Rik; BRUNOL1; CAGH4; ERDA4; Tnrc4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029784

InnateDB Gene

IDBG-170384 (Celf3)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0007283	spermatogenesis
GO:0008380	RNA splicing
GO:0030317	sperm motility
GO:0048026	positive regulation of mRNA splicing, via spliceosome