Version 5.4
Mus musculus Protein: Slc6a6
Summary
InnateDB Protein IDBP-170392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc6a6
Protein Name solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms AA589629; C80501; Taut;
Species Mus musculus
Ensembl Protein ENSMUSP00000032185
InnateDB Gene IDBG-170390 (Slc6a6)
Protein Structure
UniProt Annotation
Function Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. {ECO:0000269PubMed:1465453, ECO:0000269PubMed:22896705}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:1465453}; Multi-pass membrane protein {ECO:0000269PubMed:1465453}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:1465453, ECO:0000269PubMed:22896705}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005368 taurine transmembrane transporter activity
GO:0005369 taurine:sodium symporter activity
GO:0030977 taurine binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0015734 taurine transport
GO:0015849 organic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:98488
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002434 Sodium:neurotransmitter symporter, taurine
PFAM PF00209
PRINTS PR00176
PR01200
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35316
PhosphoSite PhosphoSite-O35316
TrEMBL Q8BRX2
UniProt Splice Variant
Entrez Gene 21366
UniGene Mm.395650
RefSeq NP_033346
MGI ID
MGI Symbol Slc6a6
OMIM
CCDS CCDS39570
HPRD
IMGT
EMBL AF020194 AK041141 AK143510 BC015245 CH466523 L03292
GenPept AAB54039 AAB70922 AAH15245 BAC30836 BAE25407 EDK99306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca