InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccnh

Summary

InnateDB Protein

IDBP-170400.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnh

Protein Name

cyclin H

Synonyms

6330408H09Rik; AI661354; AV102684; AW538719;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022030

InnateDB Gene

IDBG-170398 (Ccnh)

Protein Structure

UniProt Annotation

Function

Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in both the germinal and somatic cells of the testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301	kinase activity
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0016310	phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005675	holo TFIIH complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0070985	TFIIK complex

Protein Structure and Domains

PDB ID

MGI:1913921

InterPro

IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
IPR023598 Cyclin C
IPR027081 CyclinH/Ccl1

PFAM

PF00134

PRINTS

PIRSF

PIRSF028758

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61458

PhosphoSite

PhosphoSite-Q61458

TrEMBL

UniProt Splice Variant

Entrez Gene

66671

UniGene

RefSeq

NP_075732

MGI ID

MGI Symbol

Ccnh

OMIM

CCDS

CCDS26666

HPRD

IMGT

EMBL

AF287135 AK007910 AK078059 BC038861 X82441

GenPept

AAF90198 AAH38861 BAB25343 BAC37112 CAA57822