Version 5.4
Mus musculus Protein: Tpgs1
Summary
InnateDB Protein IDBP-170421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpgs1
Protein Name predicted gene, Gm16517
Synonyms AV005629; Gm16517; Gtrgeo22; PGs1;
Species Mus musculus
Ensembl Protein ENSMUSP00000020552
InnateDB Gene IDBG-170419 (Tpgs1)
Protein Structure
UniProt Annotation
Function May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum. {ECO:0000269PubMed:12242242, ECO:0000269PubMed:12972506, ECO:0000269PubMed:15890843}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:12972506}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269PubMed:12972506}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:12972506}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269PubMed:12972506}. Cell projection, axon {ECO:0000269PubMed:12972506}. Cell projection, dendrite {ECO:0000269PubMed:12972506}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:12972506}. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes.
Disease Associations
Tissue Specificity Broadly expressed at low levels. Highly expressed in brain. Present in brain neurons (at protein level). {ECO:0000269PubMed:12242242, ECO:0000269PubMed:12972506}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0070740 tubulin-glutamic acid ligase activity
Biological Process
GO:0007268 synaptic transmission
GO:0007275 multicellular organismal development
GO:0007288 sperm axoneme assembly
GO:0018095 protein polyglutamylation
GO:0030534 adult behavior
GO:0051648 vesicle localization
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0005929 cilium
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
Protein Structure and Domains
PDB ID MGI:106618
InterPro IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
PFAM PF02197
PRINTS
PIRSF
SMART SM00394
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MS8
PhosphoSite PhosphoSite-Q99MS8
TrEMBL B2RRP1
UniProt Splice Variant
Entrez Gene 110012
UniGene Mm.22623
RefSeq NP_683736
MGI ID
MGI Symbol Tpgs1
OMIM
CCDS CCDS23982
HPRD
IMGT
EMBL AF084937 AF303106 AK153467 BC138515 BC138516 CH466553
GenPept AAD54650 AAI38516 AAI38517 AAK15262 BAE32018 EDL31681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca