Version 5.4
Mus musculus Protein: Lzts2
Summary
InnateDB Protein IDBP-170442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lzts2
Protein Name leucine zipper, putative tumor suppressor 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000045478
InnateDB Gene IDBG-170440 (Lzts2)
Protein Structure
UniProt Annotation
Function Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255HAMAP-Rule:MF_03026}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03026}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03026, ECO:0000269PubMed:18490357}. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. {ECO:0000255HAMAP-Rule:MF_03026}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0001822 kidney development
GO:0007067 mitotic nuclear division
GO:0008285 negative regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0051013 microtubule severing
GO:0051168 nuclear export
GO:0051255 spindle midzone assembly
GO:0072001 renal system development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900181 negative regulation of protein localization to nucleus
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0030496 midbody
Protein Structure and Domains
PDB ID MGI:2385095
InterPro IPR009053 Prefoldin
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YU6
PhosphoSite PhosphoSite-Q91YU6
TrEMBL
UniProt Splice Variant
Entrez Gene 226154
UniGene Mm.28204
RefSeq NP_663478
MGI ID
MGI Symbol Lzts2
OMIM
CCDS CCDS29855
HPRD
IMGT
EMBL AC132957 AK129446 BC014695 BC092263
GenPept AAH14695 AAH92263 BAC98256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca