Version 5.4
Mus musculus Protein: Mtmr6
Summary
InnateDB Protein IDBP-170551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtmr6
Protein Name myotubularin related protein 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022563
InnateDB Gene IDBG-170549 (Mtmr6)
Protein Structure
UniProt Annotation
Function Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus envelope {ECO:0000250UniProtKB:Q9Y217}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0015269 calcium-activated potassium channel activity
GO:0016791 phosphatase activity
Biological Process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2145637
InterPro IPR003595 Protein-tyrosine phosphatase, catalytic
IPR010569 Myotubularin-like phosphatase domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF06602
PRINTS
PIRSF
SMART SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VE11
PhosphoSite PhosphoSite-Q8VE11
TrEMBL
UniProt Splice Variant
Entrez Gene 219135
UniGene Mm.473504
RefSeq NP_659092
MGI ID
MGI Symbol Mtmr6
OMIM
CCDS CCDS27176
HPRD
IMGT
EMBL AK076218 AK154859 BC020019 CH466535
GenPept AAH20019 BAC36259 BAE32884 EDL36118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca