Version 5.4
Mus musculus Protein: Fam123a
Summary
InnateDB Protein IDBP-170630.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam123a
Protein Name family with sequence similarity 123, member A
Synonyms 2600011E07Rik; Fam123a;
Species Mus musculus
Ensembl Protein ENSMUSP00000022561
InnateDB Gene IDBG-170628 (Fam123a)
Protein Structure
UniProt Annotation
Function Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0007398 ectoderm development
GO:0016055 Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1919375
InterPro IPR019003 Uncharacterised protein family FAM123
PFAM PF09422
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CCJ4
PhosphoSite PhosphoSite-Q8CCJ4
TrEMBL
UniProt Splice Variant
Entrez Gene 72125
UniGene Mm.275499
RefSeq NP_082389
MGI ID
MGI Symbol Amer2
OMIM
CCDS CCDS27177
HPRD
IMGT
EMBL AC103355 AK011185 AK032651 AK139177 BC030356 BC056350
GenPept AAH30356 AAH56350 BAB27452 BAC27972 BAE23912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca