Version 5.4
| Mus musculus Protein: Htr1f | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-170645.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Htr1f | ||||||||
| Protein Name | 5-hydroxytryptamine (serotonin) receptor 1F | ||||||||
| Synonyms | Htr1eb; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000063136 | ||||||||
| InnateDB Gene | IDBG-170643 (Htr1f) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:1328180}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:1328180}; Multi-pass membrane protein {ECO:0000269PubMed:1328180}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Detected in hippocampus. {ECO:0000269PubMed:1328180}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:99842 | ||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000450 5-Hydroxytryptamine 1F receptor IPR002231 5-hydroxytryptamine receptor family IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx IPR019426 7TM GPCR, serpentine receptor class v (Srv) IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
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| PFAM |
PF00001
PF10320 PF10323 PF10328 |
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| PRINTS |
PR00237
PR00515 PR01101 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q02284 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q543V2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 15557 | ||||||||
| UniGene | Mm.5040 | ||||||||
| RefSeq | NP_032336 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Htr1f | ||||||||
| OMIM | |||||||||
| CCDS | CCDS28267 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK045364 BC120507 BC137604 CH466521 Z14224 | ||||||||
| GenPept | AAI20508 AAI37605 BAC32328 CAA78593 EDK98243 | ||||||||