InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abce1

Summary

InnateDB Protein

IDBP-170673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abce1

Protein Name

ATP-binding cassette, sub-family E (OABP), member 1

Synonyms

C79080; Oabp; RLI; Rnaseli; RNS41;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079379

InnateDB Gene

IDBG-170671 (Abce1)

Protein Structure

UniProt Annotation

Function

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Localized to clusters of virus formation at the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0006200

ATP catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1195458

InterPro

IPR001450 4Fe-4S binding domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR007209 RNase L inhibitor RLI, possible metal-binding domain
IPR013283 ABC transporter, ABCE
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM