InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tap2

Summary

InnateDB Protein

IDBP-170754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tap2

Protein Name

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Synonyms

ABC18; Abcb3; AI462429; APT2; Ham-2; Ham2; jas; MTP2; PSF2; RING11; Tap-2; Y1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025197

InnateDB Gene

IDBG-170752 (Tap2)

Protein Structure

UniProt Annotation

Function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015197	peptide transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0046978	TAP1 binding
GO:0046980	tapasin binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015031	protein transport
GO:0015833	peptide transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:98484

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005293 Antigen peptide transporter 2
IPR011527 ABC transporter type 1, transmembrane domain
IPR013305 ABC transporter, ABCB2
IPR013306 ABC transporter, B3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PR01896
PR01897

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt