Version 5.4
Mus musculus Protein: Fgf22
Summary
InnateDB Protein IDBP-170780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgf22
Protein Name fibroblast growth factor 22
Synonyms 2210414E06Rik; FGF-22;
Species Mus musculus
Ensembl Protein ENSMUSP00000020577
InnateDB Gene IDBG-170778 (Fgf22)
Protein Structure
UniProt Annotation
Function Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Preferentially expressed in skin; low expression in brain. Expressed in the inner root sheath of the hair follicle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0008543 fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0009986 cell surface
Protein Structure and Domains
PDB ID MGI:1914362
InterPro IPR002209 Fibroblast growth factor family
IPR008996 Cytokine, IL-1-like
IPR028142 IL-1 family/FGF family
PFAM
PRINTS PR00263
PR00262
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESS2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 67112
UniGene Mm.154211
RefSeq NP_075793
MGI ID
MGI Symbol Fgf22
OMIM
CCDS CCDS23988
HPRD
IMGT
EMBL AB036765
GenPept BAB16407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca