InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hhip

Summary

InnateDB Protein

IDBP-170840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hhip

Protein Name

Hedgehog-interacting protein

Synonyms

Hhip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078047

InnateDB Gene

IDBG-170838 (Hhip)

Protein Structure

UniProt Annotation

Function

Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10050855}; Peripheral membrane protein {ECO:0000269PubMed:10050855}. Secreted {ECO:0000269PubMed:10050855}. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment.

Disease Associations

Tissue Specificity

In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the surerior colliculus. {ECO:0000269PubMed:15019948}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038	quinone binding
GO:0097108	hedgehog family protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007405	neuroblast proliferation
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0009968	negative regulation of signal transduction
GO:0016525	negative regulation of angiogenesis
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0055114	oxidation-reduction process
GO:0060441	epithelial tube branching involved in lung morphogenesis